Phototoxicity reactions with PHOTOFRIN can occur following the first exposure to direct sunlight or intense indoor light from within a few minutes to up to several hours after exposure resulting skin damage can persist. The phototoxicity with PHOTOFRIN is unique since it is activated, not only by UV light, but also by light visible to your eyes that is usually safe for humans. All patients receiving PHOTOFRIN will be sensitive to light and must take precautions to avoid exposure of eyes and skin to direct sunlight or bright indoor light for at least 30 days, but it may be required for more than 90 days. This reaction is called phototoxicity, which has a sunburn-like effect and may be severe.
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